Hidden Dangers Of Drug Interaction in Grapefruit Juice

Grapefruit juice is one of the healthiest foods around, right?

A glass of grapefruit juice with no white sugar, 100 calories, no fat, more than 100% of the recommended daily amount of vitamin C, and had a spicy flavor that can really move in the morning.

However interact with grapefruit juice (fruit grapefruit juice in their late morning) with some drugs, with potentially serious consequences.

What medications do not interact with grapefruit juice?

Grapefruit juice may interact with many medications to take people to preserve their health. If you eat grapefruit or grapefruit juice, you should consult your doctor and pharmacist of drugs that are used to check and ask again, how new drugs interact with grapefruit juice. The following list contains some of the drugs that interact with grapefruit juice. This is not an exhaustive list, if you're a fan of grapefruit, then ask your doctor before starting treatment.

Valium (diazepam): This medicine is for certain seizure disorders and anxiety.

Norvasc (amlodipine) is a drug, known as "calcium antagonists". And "to treat (chest pain related to disorders of the arteries around the heart) for angina pectoris. Grapefruit juice interacts with calcium channel blockers many

Pravachol (pravastatin): As most of the "statin" drugs used to lower cholesterol grapefruit juice can the effectiveness of this product

Cordarone (amiodarone): This medicine is used to treat the "irregular" - correct an irregular heartbeat.

What are the symptoms of these interactions?

The use of these substances during the use of grapefruit juice can lead to serious complications. E interaction was observed between the two drugs with grapefruit juice:

Valium (diazepam): Grapefruit juice can make you feel sedated and might make it harder for you to control muscle movements that can be dangerous

Norvasc (amlodipine): Grapefruit interacts with calcium antagonists, many in a very fast heart rate ("tachycardia") and / or a reduction in blood pressure at a lower level of security (food "hypotension".

Pravachol (pravastatin) statins with grapefruit juice may interact with muscle toxicity, whose symptoms include muscle weakness, pain and anxiety

Cordarone (amiodarone): Ironically, by mixing the drug with grapefruit juice in the state you want to process, thus increasing the cause - heart rhythm disturbances

What makes this potentially dangerous interaction?

How something as seemingly innocuous as grapefruit juice affects drugs that take? This is a special enzyme in the intestine and liver, which helps to absorb many oral medications, then expelled when you are done with drugs.

When a doctor writes a prescribed dose of medication (eg, 50 mg tablets), operates on the assumption that, given the size of the body because the drug in the body at a certain speed and travel at half price. The enzymes of the digestive tract (or GI) of foods and take oral medications in the body. Grapefruit juice seems to be the drug levels in your body and how fast it will affect the distance. The end result may be a drug overdose), even if you have the right amount for classification.

What can I do to avoid dangerous interactions with other medications?

If you avoid taking drugs that interact with grapefruit juice, grapefruit juice or eat grapefruit. Away from drugs and juice (such as drugs into the night to record and grapefruit for breakfast) will not solve the problem, stop the effect of grapefruit juice, even after you. If you get the benefits of grapefruit, singing or just losing that morning, the thought of switching to other crops such as tomatoes (you can only 41 calories and over 70% of vitamin C per day), or orange.

Maskalyk, J., "Grapefruit juice: potential drug interactions," Canadian Medical Association Journal, Volume 167 issue 3, p 279-80, 2002.
Shapiro, L, "Drug interactions: Proteins, pumps, and P-450s," Journal of the American Academy of Dermatology, Volume 47, issue 4, pages 467-84, 2002
Copyright (C) Shoppe.MD and Ian Mason, 2004-2005


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